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diabetes drug metformin may impair cognition It's a point that Cook acknowledges. "With our current data set, we don't know how quickly these retreat events took place," she says—or whether they occurred each time the Pliocene warmed. It may be that the ice repeatedly scoured the basin as it retreated or advanced; alternatively the basin may have been completely exposed for long periods of time. One way to try to answer these questions will be to resample the IODP core at higher resolutions, in order to track the transitions between ice-sheet retreat and no retreat.