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clindamycin phosphate gel usp 1 fougera In the last 22 years widespread prostate-specific antigen (PSA) screening has led to more prostate cancer diagnoses, but "the proportion of high Gleason score disease did not change drastically," said lead researcher Kathryn Penney, an instructor in medicine at Harvard Medical School in Boston. "This suggests that Gleason does not progress to a higher grade over time," she said.